Carmen Gil Selected Research

Glycogen Synthase Kinase 3

1/2018	Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.
12/2017	Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa.
1/2017	Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.
6/2016	New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth.
1/2016	Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy.
3/2014	Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.
1/2013	Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.
11/2012	Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.
2/2012	5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.
6/2011	Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

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Carmen Gil Research Topics

Disease

14	Infections 01/2022 - 11/2013
9	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2020 - 06/2008
8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 11/2011
7	Parkinson Disease (Parkinson's Disease) 12/2020 - 02/2011
5	Alzheimer Disease (Alzheimer's Disease) 04/2017 - 01/2011
4	Neuroinflammatory Diseases 01/2021 - 01/2011
4	Nervous System Diseases (Neurological Disorders) 04/2017 - 09/2012
3	Cognitive Dysfunction 01/2018 - 09/2013
3	Stroke (Strokes) 04/2017 - 01/2012
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2017 - 04/2012
3	Brain Injuries (Brain Injury) 02/2015 - 11/2012
2	Virus Diseases (Viral Diseases) 01/2022 - 10/2021
2	COVID-19 04/2021 - 11/2020
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2021 - 01/2016
2	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 01/2016
2	Tauopathies 12/2020 - 06/2011
2	Staphylococcal Infections 10/2020 - 09/2015
2	Fragile X Syndrome (Martin Bell Syndrome) 07/2018 - 01/2017
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2018 - 12/2017
2	Schizophrenia (Dementia Praecox) 01/2016 - 01/2013
2	Breast Neoplasms (Breast Cancer) 04/2015 - 09/2013
1	African Swine Fever 01/2022
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2021
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/2021
1	Proteostasis Deficiencies 01/2021
1	Ebola Hemorrhagic Fever 01/2021
1	Surgical Wound Infection 10/2020
1	Salmonella Infections (Salmonellosis) 01/2020
1	Schistosomiasis (Bilharziasis) 01/2019
1	Chagas Disease (American Trypanosomiasis) 01/2019
1	Leishmaniasis 10/2018
1	Blindness (Hysterical Blindness) 01/2018
1	Retinal Degeneration 01/2018
1	Retinal Dystrophies 12/2017
1	Brain Ischemia (Cerebral Ischemia) 04/2017
1	Autistic Disorder (Autism) 01/2017
1	Chronic Disease (Chronic Diseases) 01/2017
1	Demyelinating Diseases (Demyelinating Disease) 01/2017
1	Multiple Sclerosis 01/2017
1	Obesity 01/2017

Drug/Important Bio-Agent (IBA)

11	Glycogen Synthase Kinase 3IBA 01/2018 - 01/2011
10	Phosphotransferases (Kinase)IBA 01/2022 - 06/2011
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2014
9	Pharmaceutical PreparationsIBA 11/2020 - 01/2011
7	Type 7 Cyclic Nucleotide PhosphodiesterasesIBA 06/2015 - 02/2011
5	Protein Kinases (Protein Kinase)IBA 12/2020 - 01/2011
5	EnzymesIBA 12/2020 - 03/2014
4	Leucine (L-Leucine)FDA Link 12/2020 - 09/2017
4	Adenosine Monophosphate (AMP)IBA 01/2018 - 11/2013
3	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 09/2015
3	Cyclic NucleotidesIBA 01/2019 - 02/2015
3	Glycogen Synthase (Synthase I)IBA 04/2017 - 03/2014
2	Biomarkers (Surrogate Marker)IBA 04/2021 - 04/2015
2	Antiviral Agents (Antivirals)IBA 04/2021 - 01/2021
2	Biological ProductsIBA 04/2021 - 08/2017
2	Nuclear Proteins (Protein, Nuclear)IBA 01/2021 - 10/2020
2	Therapeutic UsesIBA 12/2020 - 01/2017
2	benzothiazoleIBA 12/2020 - 08/2017
2	VaccinesIBA 11/2020 - 01/2020
2	bis(3',5')-cyclic diguanylic acidIBA 01/2020 - 01/2016
2	imidazoleIBA 01/2019 - 01/2017
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2019 - 01/2011
2	GuanineIBA 07/2018 - 01/2017
2	frequenin calcium sensor proteins (neuronal calcium sensor 1)IBA 07/2018 - 01/2017
2	Retinaldehyde (Retinal)IBA 01/2018 - 12/2017
2	Blood Proteins (Serum Proteins)IBA 01/2018 - 08/2015
2	Alanine (L-Alanine)FDA Link 01/2016 - 09/2013
2	Amino Acids FDA Link 01/2016 - 09/2013
2	beta-N-methylamino-L-alanine (beta-methylamino-L-alanine)IBA 01/2016 - 09/2013
2	diethylstilbestrol monophosphate (PDES)IBA 01/2016 - 01/2011
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 02/2015 - 03/2014
2	Antimicrobial PeptidesIBA 01/2014 - 11/2013
1	Nucleic AcidsIBA 01/2022
1	tau-tubulin kinaseIBA 01/2022
1	CholesterolIBA 11/2021
1	carbazoleIBA 10/2021
1	Sulfides (Thioethers)IBA 10/2021
1	2-mercaptopurineIBA 01/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021
1	Protein AggregatesIBA 01/2021
1	Protein Kinase InhibitorsIBA 01/2021
1	UbiquitinIBA 01/2021
1	PolyphenolsIBA 11/2020
1	QuercetinIBA 11/2020
1	myricetinIBA 11/2020
1	Verteporfin (Visudyne)FDA Link 10/2020
1	DNA-Binding Proteins (DNA Binding Protein)IBA 10/2020
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	Donepezil (Aricept)FDA LinkGeneric 04/2017
1	Oxygen (Dioxygen)IBA 04/2017
1	GlutamatesIBA 04/2017
1	Glucose (Dextrose)FDA LinkGeneric 04/2017
1	Calcium Channels (Calcium Channel)IBA 04/2017
1	inulin trinicotinate monomethochloride (L-3)IBA 04/2017
1	Cholinesterases (Cholinesterase)IBA 04/2017
1	PhenothiazinesIBA 01/2017

Therapy/Procedure

13	Therapeutics 01/2022 - 01/2011
3	Catheters 11/2020 - 02/2016
1	Topical Administration 10/2020